Dudley Lamming

Associate Professor of Endocrinology, School of Medicine and Public Health

The regulation of healthy aging by what, when, and how much we eat.

dlamming@medicine.wisc.edu

(608) 262-7341

4147 UW Med Fndtn Centennial Bldg
1685 Highland Ave
Madison, WI 53705

Dr. Lamming is an Associate Professor in the Department of Medicine Division of Endocrinology, Diabetes and Metabolism at the UW-Madison School of Medicine and Public Health, and is a Research Health Scientist at William S. Middleton Memorial Veterans Hospital. Postdoctoral, Ph.D. students, M.D. students and undergraduates interested in pursuing research in the Lamming lab should contact Dr. Lamming directly at dlamming@medicine.wisc.edu.

Dr. Lamming is a member of the following centers and graduate training programs:

Education

BS, Massachusetts Institute of Technology
PhD, Harvard University
Postdoc, Whitehead Institute for Biomedical Research
Joined the UW-Madison Faculty in 2014.

The association of frailty with age and lifespan in mice differs by strain and sex

Dantong Zhu, Cara L Green, Sarah J Mitchell, Michael R Macarthur, Elise S Bisset, John Mach, Judy Z Wu, Brady A Samuelson, Anastasia Shindyapina, Alibek Moldakozhayev, Albina Tskhay, Alexander Tyshkovskiy, Vadim N Gladyshev, David A Sinclair, Susan E Howlett, Sarah N Hilmer, Dudley W Lamming, Alice E Kane

The journals of gerontology. Series A, Biological sciences and medical sciences. 2026 June 27. pmid:42363413, doi:10.1093/gerona/glag167
Bench to bedside: is rapamycin headed for the docTOR?

Dudley W Lamming

GeroScience. 2026 May 13. pmid:42126807, pmc:PMC13355979, doi:10.1007/s11357-026-02306-8
Examining widely held propositions on human dietary protein needs and benefits: a critical review of the science that shapes both the data and our understanding of an essential macronutrient

Mitchell M Kanter, Sally Aaron, Steven N Austad, Andrew W Brown, Nicholas A Burd, Wayne W Campbell, Mark Cope, Teresa A Davis, John W Erdman, Miguel Freitas, Kristen Hicks-Roof, Samuel Klein, Wantanee Kriengsinyos, Dudley W Lamming, Donald K Layman, Heather J Leidy, Kevin C Maki, Richard D Mattes, Shalene McNeill, Daniel R Moore, Stefan M Pasiakos, Stuart M Phillips, David Raubenheimer, Wendy Reinhardt, Nancy R Rodriguez, Stephen Simpson, Hans H Stein, Luc J C van Loon, Connie M Weaver, David B Allison

Critical reviews in food science and nutrition. 2026 May 8. pmid:42101036, doi:10.1080/10408398.2026.2658728
Sleeve gastrectomy improves metabolic health, cognition, and Alzheimer’s Disease pathology in 3xTG mice

Reji Babygirija, Julia A Illiano, Michelle M Sonsalla, Grace Zhu, Twinkle Mathew, Tristan Molkentin, Meredith Peterson, Carolyn Winder, Fan Xiao, Justin M Wolter, Dudley W Lamming, David A Harris

bioRxiv : the preprint server for biology. 2026 May 4. pmid:42079275, pmc:PMC13131472, doi:10.64898/2026.04.21.719988
Female resistance to the metabolic benefits of protein restriction is reversed by ovariectomy in mice

Bailey A Knopf, Isaac Grunow, Brady Anderson, Tareq Rihawi, Michelle M Sonsalla, Mariah F Calubag, Reji Babygirija, Yang Liu, Fan Xiao, Chung-Yang Yeh, Dudley W Lamming

bioRxiv : the preprint server for biology. 2026 April 22. pmid:42017010, pmc:PMC13093968, doi:10.64898/2026.03.31.715667
Toward actionable interventions in human aging (12th ARDD meeting, 2025)

Aleksandr Dekan, Sierra Lore, Ye Eun Yoon, Aisyah Sjöholm, Alexander Tyshkovskiy, Alexey Terskikh, Ana Maria Cuervo, Anastasia Georgievskaya, Andrea Heinz, Andrei Seluanov, Andrew Adams, Andy P Tsai, Anna Murray, Anne Brunet, Anne Marije van Harten, Avi Spier, Ben Shenhar, Bente Klarlund Pedersen, Berthil Clasen, Björn Schumacher, Brian K Kennedy, Charlotte Suetta, Christiane Volbracht, Christoph Kuppe, Clive Cookson, Collin Y Ewald, Cristiana Banila, Daisy Cai, Dario Riccardo Valenzano, Dudley W Lamming, Edward Rudnic, Elias Bou Samra, Emma Teeling, Eric Verdin, Evandro Fei Fang, Fabrizio d’Adda di Fagagna, Fedor Galkin, Garri Zmudze, Heinrich Jasper, In Hwa Jang, Jing-Dong Jackie Han, Jamie Justice, Jan H J Hoeijmakers, Javier María Peralta Ramos, Jean-Marc Lemaitre, Jeroen Aerssens, Joe Betts-LaCroix, John C Newman, Juan Carlos Izpisua Belmonte, Kazuto Kawamura, Kennedy Matsagas Schaal, Kitsu Egerton, Kotb Abdelmohsen, Kristen Fortney, Lars Hartenstein, Laura Niedernhofer, Lida Katsimpardi, Lisa Melton, Lotte Bjerre Knudsen, Luigi Ferrucci, Lykke Sylow, Marco Demaria, Marissa J Schafer, Marta Guasch-Ferré, Martin Borch-Jensen, Maxim Kholin, Michael Antonov, Michael Levitt, Michela Deleidi, Miriam Merad, Morten Meldal, Mourad Topors, Murali Venkatesan, Nathan K LeBrasseur, Niklas Anzinger, Peter Fedichev, Paul Kohlhaas, Peter J Mullen, Priya Singhal, Rafael de Cabo, Riekelt H Houtkooper, Rusty Montgomery, Ryan Smith, Sharon Rosenzweig-Lipson, Sergey Jakimov, Steve Horvath, Steven Austad, Thomas A Rando, Todd White, Tom Zuber, Tomaz Rozmaric, Tony Wyss-Coray, Tuomas Tammela, Vadim N Gladyshev, Vanessa V C Sinatti, Weilan Wang, William Harborne, Xiaodong Liu, Xing Li Wang, Yousin Suh, Yuta Lee, Zane Koch, Alex Zhavoronkov, Morten Scheibye-Knudsen, Daniela Bakula

Aging. 2026 April 7. pmid:41944812, pmc:PMC13285953, doi:10.18632/aging.206368
Restriction of Individual Branched-Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer’s Disease in 3xTg Mice

Reji Babygirija, Cara L Green, Michelle M Sonsalla, Izabelle Marie F Le, Fan Xiao, Sarah Yandell, Mariah F Calubag, Michaela E Trautman, Anna Tobon, Ryan Matoska, Chung-Yang Yeh, Charles I Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A Knopf, Michael J Rigby, David A Harris, Mark P Keller, Alan D Attie, Luigi Puglielli, Cholsoon Jang, Dudley W Lamming

Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2026 March 12. pmid:41817439, pmc:PMC13248761, doi:10.1002/advs.202515220
Past, present and future perspectives on the science of aging

Fabrisia Ambrosio, Maxim N Artyomov, Steven N Austad, Nir Barzilai, Juan Carlos Izpisua Belmonte, Daniel W Belsky, Bérénice A Benayoun, Anne Brunet, Handan Melike Dönertaş, Dena B Dubal, Evandro F Fang, Jerome N Feige, Linda P Fried, David Furman, Xu Gao, Vadim N Gladyshev, Vera Gorbunova, Myriam Gorospe, Jing-Dong J Han, Oskar Hansson, Eiji Hara, Steve Horvath, Nancy Y Ip, George A Kuchel, Matt Kaeberlein, Dudley W Lamming, Becca R Levy, Guang-Hui Liu, Jinkook Lee, Terrie E Moffitt, Tohru Minamino, Linda Partridge, Parminder Raina, Thomas A Rando, John W Rowe, Michal Schwartz, Andrew J Scott, Felipe Sierra, David A Sinclair, Charlotte E Teunissen, Bruno Vellas, Eric Verdin, Keenan A Walker, Ashley E Webb, Tony Wyss-Coray, Ming Xu, Jin-Tai Yu, Alex Zhavoronkov, Yahyah Aman, Anna Kriebs, Qingzhong Ren, Hannah Walters, Sebastien Thuault

Nature aging. 2026 January 21. pmid:41566049, doi:10.1038/s43587-025-01046-2
The Sixth Annual Symposium of the Midwest Aging Consortium

Ines Sturmlechner, Sarah A Ashiqueali, Hélène Martini, Karla Valdivieso, Ana Catarina Franco, Prashanth Guthikonda, Andrew J Dosch, Luis I Prieto, Niels C Asmussen, Amanda S Latham, James T Redden, Ethan A Leitschuh, Douglas G Mashek, João F Passos, Jhonny Rodriguez-Lopez, T Blake Monroe, David A Bernlohr, Paul D Robbins, Bailey A Knopf, Dudley W Lamming, Matthew J Johnston, Holly M Brown-Borg, Spencer A Tye, Timothy W Rhoads, David M Gate, Bennett G Childs, Darren J Baker, Xinna Li, In Hwa Jang, Christina D Camell, Zachary Miller, Hemali Phatnani, Adam R Konopka, Andrew J Haak, Natalia Vanegas-Avendano, Ramya N Akula, Ajinkya R Limkar, William A Ricke, Scott F Leiser, Jacinta Correia, Hua Bai, Szczepan Olszewski, Kenneth L Seldeen, G R Scott Budinger, Luisa C Morales-Nebreda, Deborah R Winter, Shelly K McCrady-Spitzer, Rozalyn M Anderson, Maria M Mihaylova, Mauricio Rojas, Ana L Mora, Nathan K LeBrasseur, Marissa J Schafer

The journals of gerontology. Series A, Biological sciences and medical sciences. 2025 December 22. pmid:41429578, pmc:PMC12764364, doi:10.1093/gerona/glaf280
Depletion of individual dietary amino acids induce distinct metabolic and chromatin states

Spencer A Haws, Yang Liu, Cara L Green, Krittisak Chaiyakul, Pragyan Mishra, Reji Babygirija, Eric A Armstrong, Anusha T Mehendale, Irene M Ong, Dudley W Lamming, John M Denu

The Journal of biological chemistry. 2025 December 19. pmid:41419194, pmc:PMC12816912, doi:10.1016/j.jbc.2025.111074

Our goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity. Rapamycin, an inhibitor of the protein kinase mTOR, can improve both health and longevity in model organisms including mammals. Understanding and manipulating the mTOR signaling pathway through dietary, pharmaceutical or genetic interventions may provide insight into the treatment of age-related diseases, including diabetes, Alzheimer’s disease, cancer, and Hutchinson-Gilford Progeria Syndrome.