Lauren Lucas

Gut microbes mediate the synergistic effects of dietary cholesterol and saturated fat in driving fibrosing MASH

Jake B Hermanson, Samar A Tolba, Md Amran Gazi, Evan A Chrisler, Manpreet Kaur, Ashley M Sidebottom, Yongjun Liu, Guillermo Martinez-Boggio, Lauren N Lucas, Daniel Amador-Noguez, Federico E Rey, Vanessa A Leone

Gut microbes. 2026 May 11. pmid:42108649, pmc:PMC13166192, doi:10.1080/19490976.2026.2668121

Investigation of bile salt hydrolase activity in human gut bacteria reveals production of conjugated secondary bile acids

Lauren N Lucas, Mallikarjun Jillella, Lea E Cattaneo, Bhavana Gangwar, Qijun Zhang, A P Clay, Robert L Kerby, David M Stevenson, Helen E Blackwell, Federico E Rey, Daniel Amador-Noguez

Nature communications. 2026 February 23. pmid:41730843, pmc:PMC13039732, doi:10.1038/s41467-026-68556-4

GPR41 deficiency alters the gut microbiota-bile acid axis, reduces ileal expression of Npc1l1, and attenuates hypercholesterolemia in male mice

Evan R Hutchison, Jillella Mallikarjun, Jung Ha Byun, Lauren N Lucas, Kazuyuki Kasahara, Michael Tallon, Qijun Zhang, Daniel Amador-Noguez, Yongjun Liu, Vanessa A Leone, Brian W Parks, Federico E Rey

Gut microbes. 2025 December 15. pmid:41395766, pmc:PMC12710913, doi:10.1080/19490976.2025.2598957

Gut microbes mediate the synergistic effects of dietary cholesterol and saturated fat in driving fibrosing MASH

Jake B Hermanson, Samar A Tolba, Md Amran Gazi, Evan A Chrisler, Manpreet Kaur, Ashley M Sidebottom, Yongjun Liu, Guillermo Martinez-Boggio, Lauren N Lucas, Daniel Amador-Noguez, Federico E Rey, Vanessa A Leone

bioRxiv : the preprint server for biology. 2025 August 8. pmid:40777228, pmc:PMC12330582, doi:10.1101/2025.07.16.665145

Portal bile acid composition and microbiota along the murine intestinal tract exhibit sex differences in physiology

François Reichardt, Lauren N Lucas, Lydia Okyere, Jim Choi, Daniel Amador-Noguez, Christopher A Gaulke, Sayeepriyadarshini Anakk

Gut microbes. 2025 August 5. pmid:40760771, pmc:PMC12326574, doi:10.1080/19490976.2025.2540483

Allosteric regulation of pyruvate kinase enables efficient and robust gluconeogenesis by preventing metabolic conflicts and carbon overflow

Fukang She, Brent W Anderson, Daven B Khana, Shenwei Zhang, Wieland Steinchen, Danny K Fung, Nathalie G Lesser, Lauren N Lucas, David M Stevenson, Theresa J Astmann, Gert Bange, Jan-Peter van Pijkeren, Daniel Amador-Noguez, Jue D Wang

mSystems. 2025 January 28. pmid:39873491, pmc:PMC11834443, doi:10.1128/msystems.01131-24

Investigation of Bile Salt Hydrolase Activity in Human Gut Bacteria Reveals Production of Conjugated Secondary Bile Acids

Lauren N Lucas, Jillella Mallikarjun, Lea E Cattaneo, Bhavana Gangwar, Qijun Zhang, Robert L Kerby, David Stevenson, Federico E Rey, Daniel Amador-Noguez

bioRxiv : the preprint server for biology. 2025 January 27. pmid:39868271, pmc:PMC11760432, doi:10.1101/2025.01.16.633392