Food and Nutritional Sciences

    College of Agricultural & Life Sciences

    UNIVERSITY of WISCONSIN-MADISON UW-MADISON

    Timothy Rhoads

    he/him

    Assistant Professor of Nutritional Sciences

    Caloric restriction, metabolism, biology of aging, systems biology, gene expression regulation

    timothy.rhoads@wisc.edu

    (608) 265-6727

    Website

    Type: ,
    • Assistant Professor of Nutritional Sciences
    • BS 2007, Gonzaga University
    • PhD 2012, Oregon State University
    • Microbial metabolism of methotrexate produces a STAT3 signaling molecule that alleviates gut inflammation

      Juyeong Cho, Rebecca Danner, Woo Sung Kim, Jonathan Williams, Anshit Singh, Jiyoung A Han, Jonathan G Van Vranken, Allison S Walker, Timothy Rhoads, Snehal N Chaudhari

      bioRxiv : the preprint server for biology. pmid:41959532, pmc:PMC13060975, doi:10.64898/2026.03.11.711168

    • Adiponectin and aging: Mechanistic insights, clinical paradox, and therapeutic horizons

      Eric R McGregor, Katie J Osterbauer, Grace E Gustafson, Josef P Clark, Timothy W Rhoads, Rozalyn M Anderson

      Ageing research reviews. pmid:41690624, pmc:PMC13215238, doi:10.1016/j.arr.2026.103059

    • The Sixth Annual Symposium of the Midwest Aging Consortium

      Ines Sturmlechner, Sarah A Ashiqueali, Hélène Martini, Karla Valdivieso, Ana Catarina Franco, Prashanth Guthikonda, Andrew J Dosch, Luis I Prieto, Niels C Asmussen, Amanda S Latham, James T Redden, Ethan A Leitschuh, Douglas G Mashek, João F Passos, Jhonny Rodriguez-Lopez, T Blake Monroe, David A Bernlohr, Paul D Robbins, Bailey A Knopf, Dudley W Lamming, Matthew J Johnston, Holly M Brown-Borg, Spencer A Tye, Timothy W Rhoads, David M Gate, Bennett G Childs, Darren J Baker, Xinna Li, In Hwa Jang, Christina D Camell, Zachary Miller, Hemali Phatnani, Adam R Konopka, Andrew J Haak, Natalia Vanegas-Avendano, Ramya N Akula, Ajinkya R Limkar, William A Ricke, Scott F Leiser, Jacinta Correia, Hua Bai, Szczepan Olszewski, Kenneth L Seldeen, G R Scott Budinger, Luisa C Morales-Nebreda, Deborah R Winter, Shelly K McCrady-Spitzer, Rozalyn M Anderson, Maria M Mihaylova, Mauricio Rojas, Ana L Mora, Nathan K LeBrasseur, Marissa J Schafer

      The journals of gerontology. Series A, Biological sciences and medical sciences. pmid:41429578, pmc:PMC12764364, doi:10.1093/gerona/glaf280

    • Aging-linked systemic lipid signature is reprogrammed by caloric restriction in rhesus monkeys

      Salma I Abou Elhassan, Josef P Clark, Di Kuang, Timothy W Rhoads, Ricki J Colman, Joshua J Coon, Rozalyn M Anderson, Katherine A Overmyer

      Molecular systems biology. pmid:41372706, pmc:PMC12864875, doi:10.1038/s44320-025-00177-3

    • Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism

      Orion S Willoughby, Anna S Nichenko, Matthew H Brisendine, Niloufar Amiri, Shelby N Henry, Daniel S Braxton, John R Brown, Braeden J Kraft, Kalyn S Jenkins, Adele K Addington, Alexey V Zaitsev, Steven T Burrows, Ryan P McMillan, Haiyan Zhang, Spencer A Tye, Charles P Najt, Siobhan E Craige, Timothy W Rhoads, Junco S Warren, Joshua C Drake

      Molecular metabolism. pmid:41297881, pmc:PMC12720300, doi:10.1016/j.molmet.2025.102288

    • Caloric Restriction Reprograms Adipose Tissues in Rhesus Monkeys

      Josef P Clark, Timothy W Rhoads, Sean J McIlwain, Michael A Polewski, Derek M Pavelec, Ricki J Colman, Rozalyn M Anderson

      Aging cell. pmid:41042069, pmc:PMC12686577, doi:10.1111/acel.70254

    • Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism

      Orion S Willoughby, Anna S Nichenko, Matthew H Brisendine, Niloufar Amiri, Shelby N Henry, Daniel S Braxton, John R Brown, Braeden J Kraft, Kalyn S Jenkins, Adele K Addington, Alexey V Zaitsev, Steven T Burrows, Ryan P McMillan, Haiyan Zhang, Spencer A Tye, Charles P Najt, Siobhan E Craige, Timothy W Rhoads, Junco S Warren, Joshua C Drake

      bioRxiv : the preprint server for biology. pmid:40631262, pmc:PMC12236709, doi:10.1101/2025.06.30.662412

    • Caloric restriction reprograms adipose tissues in rhesus monkeys

      Josef P Clark, Timothy W Rhoads, Sean J McIlwain, Michael A Polewski, Derek M Pavelec, Ricki J Colman, Rozalyn M Anderson

      bioRxiv : the preprint server for biology. pmid:40093109, pmc:PMC11908232, doi:10.1101/2025.03.03.641286

    • Neuron-specific isoform of PGC-1α regulates neuronal metabolism and brain aging

      Dylan C Souder, Eric R McGregor, Josef P Clark, Timothy W Rhoads, Tiaira J Porter, Kevin W Eliceiri, Darcie L Moore, Luigi Puglielli, Rozalyn M Anderson

      Nature communications. pmid:40021651, pmc:PMC11871081, doi:10.1038/s41467-025-57363-y

    • Geroprotector drugs and exercise: friends or foes on healthy longevity?

      Christian J Elliehausen, Rozalyn M Anderson, Gary M Diffee, Timothy W Rhoads, Dudley W Lamming, Troy A Hornberger, Adam R Konopka

      BMC biology. pmid:38066609, pmc:PMC10709984, doi:10.1186/s12915-023-01779-9

    Work in the GERAM (Gene Expression Regulation of Aging and Metabolism) lab, directed by Dr. Rhoads, focuses on understanding the molecular regulation of aging and metabolism through the use of caloric restriction (CR). CR is a dietary intervention and model of delayed aging; CR results in extended lifespan in numerous model organisms. This is of direct relevance for human health, as advanced age is the largest risk factor for numerous chronic diseases – cancer, diabetes, cardiovascular disease, and neurodegeneration, to name a few. However, the molecular mechanisms connecting reduced caloric intake with enhanced longevity and reduced chronic disease vulnerability remain poorly understood. The GERAM lab focuses on mechanisms of gene expression regulation, including protein post-translational modification, mRNA processing, and expression regulation via endogenous small RNA. Tools used include both wet lab and dry lab analytical methods, with a substantial interest in integrative models that produce systems-level insights.

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