Food and Nutritional Sciences

    College of Agricultural & Life Sciences

    UNIVERSITY of WISCONSIN-MADISON UW-MADISON

    Alan Attie

    Professor of Biochemistry

    Genetics of obesity, diabetes, and metabolic diseases. Genetics of diet responsiveness.

    attie@biochem.wisc.edu

    (608) 262-1372

    Website

    543A HF DeLuca Biochemistry Laboratories
    433 Babcock Drive
    Madison, WI 53706-1544

    Type: ,

    B.S., University of Wisconsin-Madison
    Ph.D., University of California-San Diego

    Genetic Pipeline

    Our projects come from genes we identify in our screens using mouse genetics. We then study these genes in transgenic mice and in cell lines.

    Gene causal networks and diabetes

    By combining global gene expression profiling and genetics, we are able to construct causal networks linking specific genes with diabetes phenotypes. One of those genes is the transcription factor NFATc2. We are studying its regulation in relation to β-cell function and diabetes.

    Genetics of metabolic outcome

    There is tremendous variability in the response of individuals to different diets. Likewise, mouse strains vary in their response to diet. These responses are due to differences in the control of metabolic pathways. We are conducting a genetic screen using stable isotope tracers to measure metabolic outcome through many pathways in mice subjected to two extreme diets. We will map the genetic drivers responsible for strain differences in diet responsiveness

    grow magazine article, Spring 2015, about Attie’s Diabetes research click here.

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