Nathan Welham

Professor of Surgery

Vocal fold mucosal biology; head and neck disorders; regenerative medicine; retinoid biology; proteomics with a particular focus on extracellular matrix, protein turnover, & tissue remodeling.

welham@surgery.wisc.edu

Wisconsin Institutes for Medical Research (WIMR) BLDG. 1485
1111 Highland Ave.
Madison, WI 53705-2275

Type: Affiliate Faculty, MANTP Trainer

Education

BSLT (Hons I), University of Canterbury, Christchurch, New Zealand
MSLT (Dist), University of Canterbury, Christchurch, New Zealand
PhD, University of Wisconsin-Madison, Madison, WI

Rapid expansion of primary human vocal fold epithelial cells via targeted pathway inhibition and anchorage-independent sphere culture

Xudong Shi, Ryo Suzuki, Haiyan Lu, Hua Zhang, Lingjun Li, Nathan V Welham

Cell reports methods. 2026 March 7. pmid:41794022, pmc:PMC13030965, doi:10.1016/j.crmeth.2026.101310
Agreement Between Hypernasality Ratings and Nasalance Scores in Spanish-English Bilingual Patients with Cleft Palate

Jacqueline Burpee, Evalise Dexter, John H Munday, Nathan V Welham

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. 2025 December 26. pmid:41451897, pmc:PMC12828910, doi:10.1177/10556656251405745
Synthesis of 13C2-Retinyl Acetate and Dose Preparation for Retinol Isotope Dilution Tests

Sherry A Tanumihardjo, Jesse Sheftel, Khushi Tanna, Molly Fjalstad, Nathan V Welham, Christopher R Davis, Bryan M Gannon

Journal of visualized experiments : JoVE. 2025 September 8. pmid:40920613, pmc:PMC12591300, doi:10.3791/68535
Single-cell lipidomics enabled by dual-polarity ionization and ion mobility-mass spectrometry imaging

Hua Zhang, Yuan Liu, Lauren Fields, Xudong Shi, Penghsuan Huang, Haiyan Lu, Andrew J Schneider, Xindi Tang, Luigi Puglielli, Nathan V Welham, Lingjun Li

Nature communications. 2023 August 25. pmid:37626051, pmc:PMC10457347, doi:10.1038/s41467-023-40512-6
On-tissue amidation of sialic acid with aniline for sensitive imaging of sialylated N-glycans from FFPE tissue sections via MALDI mass spectrometry

Hua Zhang, Xudong Shi, Yuan Liu, Bin Wang, Meng Xu, Nathan V Welham, Lingjun Li

Analytical and bioanalytical chemistry. 2022 January 24. pmid:35072748, pmc:PMC9381140, doi:10.1007/s00216-022-03894-y
An atlas of protein turnover rates in mouse tissues

Zach Rolfs, Brian L Frey, Xudong Shi, Yoshitaka Kawai, Lloyd M Smith, Nathan V Welham

Nature communications. 2021 November 27. pmid:34836951, pmc:PMC8626426, doi:10.1038/s41467-021-26842-3
Quantification and molecular imaging of fatty acid isomers from complex biological samples by mass spectrometry

Hua Zhang, Meng Xu, Xudong Shi, Yuan Liu, Zihui Li, Justin C Jagodinsky, Min Ma, Nathan V Welham, Zachary S Morris, Lingjun Li

Chemical science. 2021 July 1. pmid:34194701, pmc:PMC8208125, doi:10.1039/d1sc01614h
High-resolution magnetic resonance and mass spectrometry imaging of the human larynx

Ayami Ohno Kishimoto, Yo Kishimoto, Xudong Shi, Elizabeth B Hutchinson, Hua Zhang, Yatao Shi, Gisele Oliveira, Lingjun Li, Nathan V Welham, Ian J Rowland

Journal of anatomy. 2021 May 25. pmid:34032275, pmc:PMC8349453, doi:10.1111/joa.13451
On-Tissue Derivatization with Girard’s Reagent P Enhances N-Glycan Signals for Formalin-Fixed Paraffin-Embedded Tissue Sections in MALDI Mass Spectrometry Imaging

Hua Zhang, Xudong Shi, Nhu Q Vu, Gongyu Li, Zihui Li, Yatao Shi, Miyang Li, Bin Wang, Nathan V Welham, Manish S Patankar, Paul Weisman, Lingjun Li

Analytical chemistry. 2020 September 1. pmid:32865977, pmc:PMC7544651, doi:10.1021/acs.analchem.0c02704
Proteomic and Genomic Methylation Signatures of Idiopathic Subglottic Stenosis

Stephen S Schoeff, Xudong Shi, William G Young, Chad W Whited, Resha S Soni, Peng Liu, Irene M Ong, Seth H Dailey, Nathan V Welham

The Laryngoscope. 2020 July 4. pmid:32619300, pmc:PMC7779687, doi:10.1002/lary.28851

Dr. Welham’s research interests include vocal fold mucosal biology; extracellular matrix-focused proteomics; and vitamin A transport, storage and function.

Dr. Welham was awarded a five-year, $2.7 million research grant from the National Institute on Deafness and Other Communication Disorders. Read more here.

Certificates: American Speech Language Hearing Association Certificate of Clinical Competency
Licenses: Speech, Language Pathology