Snehal Chaudhari

Assistant Professor of Biochemistry

Study of small molecules abundantly present in the gut that are substantially synthesized and modulated by gut bacteria, and how they influence health and disease.

snchaudhari@wisc.edu

(608) 263-0612

Website

441B HF DeLuca Biochemistry Laboratories
433 Babcock Drive
Madison, WI 53706-1544

Type: Affiliate Faculty, MANTP Trainer

B.Tech., Dr. D. Y. Patil University, Mumbai, India
M.S., Pennsylvania State University, University Park, PA
Ph.D., University of Georgia, Athens, GA
Postdoctoral, Harvard Medical School, Boston, MA

Rational Design and Evaluation of Novel TGR5 Agonists for Diabetes

Rachana S Bhimanwar, Zachary Detwiler, Jinge G Zhu, Samuel T Saghafi, Carolyn A Winder, Dawn Belt Davis, Amit Mittal, Vikas Sharma, David A Harris, Snehal N Chaudhari

Molecules (Basel, Switzerland). 2026 April 14. pmid:41976136, pmc:PMC13075183, doi:10.3390/molecules31071093
Microbial metabolism of methotrexate produces a STAT3 signaling molecule that alleviates gut inflammation

Juyeong Cho, Rebecca Danner, Woo Sung Kim, Jonathan Williams, Anshit Singh, Jiyoung A Han, Jonathan G Van Vranken, Allison S Walker, Timothy Rhoads, Snehal N Chaudhari

bioRxiv : the preprint server for biology. 2026 April 10. pmid:41959532, pmc:PMC13060975, doi:10.64898/2026.03.11.711168
Sleeve gastrectomy protects lean mice from future obesity

Andrei Moscalu, Reji Babygirijia, Twinkle Mathew, Snehal N Chaudhari, David Zhang, Lei Zhou, Eric G Sheu, David A Harris

bioRxiv : the preprint server for biology. 2026 April 10. pmid:41959063, pmc:PMC13060873, doi:10.64898/2026.03.09.710623
Atlas of one-carbon metabolism in conventional and germ-free mice reveals folate as a key determinant of biochemical pathways

Jonathan Williams, Woo Sung Kim, Rebecca Danner, Juyeong Cho, Bianca F Silva, David A Harris, Federico E Rey, Snehal N Chaudhari

Nature metabolism. 2026 March 27. pmid:41888596, pmc:PMC13121008, doi:10.1038/s42255-026-01489-w
Bile salt hydrolase activity as a rational target for MASLD therapy

Elizabeth V Jones, Yongtao Wang, Wenchao Wei, James C Reed, Snehal N Chaudhari, Darrick K Li, Jerome Boursier, Sonja Lang, Münevver Demir, Anna Mae Diehl, Andrew S Allegretti, Bernd Schnabl, Raymond T Chung, A Sloan Devlin

Gut microbes. 2026 January 2. pmid:41481156, pmc:PMC12773562, doi:10.1080/19490976.2025.2608437
BAAT away liver cancer: conjugated bile acids impair T cell function in hepatocellular carcinoma immunotherapy

Zachary Detwiler, Snehal N Chaudhari

Immunometabolism (Cobham, Surrey). 2025 May 12. pmid:40352823, pmc:PMC12063675, doi:10.1097/IN9.0000000000000062
Alterations in intestinal bile acid transport provide a therapeutic target in patients with post-bariatric hypoglycaemia

Snehal N Chaudhari, Yingjia Chen, Rafael Ferraz-Bannitz, Cameron Cummings, Amanda Sheehan, Pilar Casanova Querol, Berkcan Ozturk, Hanna Wang, Gabriel D’Agostino, Fei Ye, Eric G Sheu, A Sloan Devlin, Mary-Elizabeth Patti

Nature metabolism. 2025 April 4. pmid:40186075, pmc:PMC12476230, doi:10.1038/s42255-025-01262-5
Recent advancements in the structural exploration of TGR5 agonists for diabetes treatment

Rachana S Bhimanwar, Amit Mittal, Snehal Chaudhari, Vikas Sharma

RSC medicinal chemistry. 2024 September 23. pmid:39309359, pmc:PMC11411620, doi:10.1039/d4md00473f
A small intestinal bile acid modulates the gut microbiome to improve host metabolic phenotypes following bariatric surgery

Yingjia Chen, Snehal N Chaudhari, David A Harris, Cullen F Roberts, Andrei Moscalu, Vasundhara Mathur, Lei Zhao, Ali Tavakkoli, A Sloan Devlin, Eric G Sheu

Cell host & microbe. 2024 July 23. pmid:39043190, pmc:PMC11332993, doi:10.1016/j.chom.2024.06.014
Host-microbiome orchestration of the sulfated metabolome

Gabriel D D’Agostino, Snehal N Chaudhari, A Sloan Devlin

Nature chemical biology. 2024 February 12. pmid:38347214, pmc:PMC11095384, doi:10.1038/s41589-023-01526-9

Compositions and methods related to cholic acid-7-sulfate as a treatment for diabetes
WO/2020/041673 link

Synthetic derivatives of cholic acid-7-sulfate and uses thereof
WO/2020/117945 link